In this paper, presents case studies on vegetable legumes and leafy brassicas – the two most important crops in Southeast Asia – especially from Cambodia, Lao PDR and Vietnam. Since the pesticide misuse has been documented on these crops, it has become highly imperative to develop, validate and scale-out effective a alternatives to reduce pesticide misuse in vegetable production. Integrated pest management (IPM) packages have been developed using pheromones, bio-pesticides and need-based applications of selective pesticides. They were validated in on-station as well as farmer participatory trials in Cambodia, Lao PDR and Vietnam. Multi-location trials confirmed that the performance of the IPM package was on par with farmers’ practices (calendar-based application of chemical pesticides) in reducing the infestation by target pests, without compromising yield. In addition, the IPM package also supported the proliferation of natural enemies in vegetable production systems. Furthermore, these IPM packages can play a greater role in safer vegetable production. However, majority of the farmers in Southeast Asia still do not have access to most of the IPM inputs including bio-pesticides. Hence, a public-private partnership has become inevitable to introduce and promote IPM products, considering also the recent progress made on the harmonization of regulatory procedures for registration of bio-control agents across Southeast Asia, which can expedite the introduction of IPM products in this region.