The detrimental effects and mutagenical potential of Schiff base sulfadiazine derivative engineered particles on Allium cepa (L)

The detrimental effects and mutagenical potential of Schiff base sulfadiazine derivative engineered particles on Allium cepa (L)

2014

E09279

The objective of this work carried to evaluate the effects of two doses (50 and 100 mg) of Schiff base\n sulfadiazine derivative (SDD) engineered particles (EPs), at time intervals 3, 6, and 12 (hrs), on the contents of the genetic material (DNA & RNA), soluble proteins as well as cell division and chromosomal behaviour of root meristems of Allium cepa (onion bulbs) as a tested material. Scan Electron Microscope (SEM) studies revealed that\n ovoid-to rectangular-shaped SDD were present as clusters with an average particle size of 696 ± 17.5 nm. The obtained data showed that the contents of nucleic acids and total soluble proteins in root meristems of Allium cepa were found to be decreased by increasing both the concentration and time of exposure. Regarding the effect of SDD\n on the mitotic index (MI) and chromosome instability of onion root tips, the results showed significant reductions in MI accompanied by high significantly increased in the total percent of chromosomal abnormalities. Different types of chromosomal aberrations were induced following the exposure to the engineered particles of SDD such as disturbed chromosomes, chromosomal stickiness, laggards, chromosomal fragmentation and diagonal (disorientation of spindle fibers). Our investigation suggests that plant cells as an important marker of the ecosystems need to be\n included when evaluating the overall toxicological impact of the engineered particles in the environment.

6(2):48-58, REPORT AND OPINION

Research > Published Articles