Characterization of anti-inflammatory activities and antinociceptive effects of papaverine from Sauropus androgynus (L.) Merr

Characterization of anti-inflammatory activities and antinociceptive effects of papaverine from Sauropus androgynus (L.) Merr

2012

E06481

The present study was aimed to investigate the anti-inflammatory activity of papaverine from Sauropus androgynus L. Merr. (Phyllanthaceae) using experimentally induced inflammatory models in rats. In vitro anti-inflammatory activity by Inhibition of albumin denaturation, Membrane stabilization test, Heat induced hemolytic activity, Protein inhibitory action and In vitro anti-inflammatory activity by Carrageenan Induced Rat Paw Edema Method, Antinociceptive activity, Hot-Plate Test. Sauropus androgynus showed significant reduction when compared with the standard dose of 100 mg/kg b.wt Papaverine, Morphine which exhibited stronger inhibition than aminopurine in acetic-acid induced abdominal stretching at 100 mg/kg dose. Papaverine also showed antinociceptive activity at 100 mg/kg dose in tail-flick test. However, of Sauropus androgynus at doses of 200 mg/kg and 400mg/kg b.wt showed a significant reduction with 59.2 % and 51.5 %, respectively in rat paw oedema induced by carrageenan against the reference anti-inflammatory drug Phenylbutazone 100 mg/kg of 48.2% in 1hr. This study shows significant reduction in paw edema and significant increased reaction time in tail flick test were observed at a dosage of 400 mg/kg/body weight.

6(3):186-192, GLOBAL JOURNAL OF PHARMACOLOGY

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