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Bronchospasmolytic activity of the extract and fractions of Asystasia gangetica leaves
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The bronchospasmolytic constituent of leaves of Asystasia gangetica (L.) T. Anderson, sub-specie micrantha (Nees) Ensermu (Acanthaceae) was isolated by bio-activity-guided technique. The bronchospasmolytic effect of the fractions of the leaf extract as well as the isolate AG-1 was evaluated using histamine-induced contraction of the guinea pig trachea and pre-contracted trachea (pathological tissue). The results showed that the fractions and AG-1 inhibited contractions of the guinea pig trachea induced by histamine in a dose dependent manner. The isolated constituent, (AG-1) caused 82% inhibition of maximal contraction produced by histamine at a concentration of 400μg/ml. On histamine (8μg/ml) pre-contracted trachea, cumulative doses of the fractions evoked a dose dependent relaxation. Phytochemical analysis showed that the isolated compound (AG-1) tested positive to terpenoids while the fractions contained typical constituents such as carbohydrates, alkaloids, saponins, steroids, flavonoids and glycosides. These findings suggest that the usefulness of leaves of A. gangetica in the treatment of asthma may derive from bronchospasmolytic effect of terpenoid compounds in the leaves.
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 Record created 2017-10-01, last modified 2019-06-17

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