Soybean toxin (SBTX), a protein from soybeans that inhibits the life cycle of plant and human pathogenic fungi
2010
E03380
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Title
Soybean toxin (SBTX), a protein from soybeans that inhibits the life cycle of plant and human pathogenic fungi
Author
Morais, J.K.S.
Gomes, V.M.
Oliveira, J.T.A.
Santos, I.S.
Cunha, M.D.
Oliveria, H.D.
Oliveira, H.P.
Sousa, D.O.B.
Vasconcelos, I.M.
Gomes, V.M.
Oliveira, J.T.A.
Santos, I.S.
Cunha, M.D.
Oliveria, H.D.
Oliveira, H.P.
Sousa, D.O.B.
Vasconcelos, I.M.
Publication Date
2010
Call Number
E03380
Summary
Soybean toxin (SBTX) is a 44 kDa glycoprotein that is lethal to mice (LD50 = 5.6 mg/kg). This study reports the toxicity of SBTX on pathogenic fungi and yeasts and the mechanism of its action. SBTX inhibited spore germination of Aspergillus niger and Penicillium herguei and was toxic to Candida albicans, Candida parapsilosis, Kluyveromyces marxiannus, Pichia membranifaciens, and Saccharomyces cerevisiae. In addition, SBTX hampered the growth of C. albicans and K. marxiannus and inhibited the glucose-stimulated acidification of the incubation medium by S. cerevisiae, suggesting that SBTX interferes with intracellular proton transport to the external medium. Moreover, SBTX caused cell-wall disruption, condensation/shrinkage of cytosol, pseudohyphae formation, and P. membranifaciens and C. parapsilosis cell death. SBTX is toxic to fungi at concentrations far below the dose lethal to mice andhas potential in the design of new antifungal drugs or in the development of transgenic crops resistant to pathogens.
Journal Citation
v.58(19):10356-10363, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Contact Information
harvest@worldveg.org
Record Appears in
Research > Published Articles