For the past five decades, the World Vegetable Center (WorldVeg) has conducted research to improve vegetable varieties and production systems that are adapted to the high temperatures and weather extremes in the tropical and sub-tropical regions with significant achievements and impact. By leveraging these achievements, WorldVeg is well positioned to expand its research portfolio to develop climate change adaptation and mitigation options along the vegetable value chain. These options should sustain or ideally enhance vegetable productivity and quality when averaged over a number of growing seasons despite climate change, reduce inter-season variability due to weather extremes, and limit post-harvest losses. In this paper, first risks of the vegetable value chain stakeholders to climate change are described. Next, the likely effects of climate change on vegetable productivity, and its subsequent effects along the vegetable value chain are discussed. This is followed by a description of mutually re-enforcing strategies that can be adopted by WorldVeg and partners to build climate resilience along the vegetable value chain.